This research focuses on addressing the urgent need for faster, more accessible tuberculosis (TB) screening in South Africa. Dr Stephan Schoeman developed a portable, low-cost electrochemical biosensor designed to detect TB-related biomarkers quickly at the point of care, reducing reliance on complex laboratory infrastructure. Through iterative prototyping, the team engineered a compact, disposable device using carbon nanofibre electrodes and a layered design with built-in test validation. The final sensor (Sensor M) demonstrated high sensitivity across clinically relevant ranges by detecting C-reactive protein (CRP), delivering reliable results within minutes. The biosensor’s affordability, ease of use, and adaptability make it a promising tool for use in resource-limited settings such as mobile clinics. Beyond TB, the platform has potential applications in diagnosing other diseases, supporting broader public health efforts. Next steps include clinical validation, scaling up manufacturing, and expanding the device to detect multiple biomarkers simultaneously, further improving diagnostic accuracy and impact.