​RIRCA, the Reproductive Immunology Research Consortium in Africa at Stellenbosch University (SU), was conceived as a hub for research training in immunology techniques and hypothesis-driven research. Situated in an environment grappling with a significant disease burden of HIV, our research primarily centres on the characteristics and functional capabilities of adaptive and innate immune cells within the placenta. This focus extends to HIV-exposed uninfected newborn infants (HEU), holding profound relevance in unveiling irregularities within immune regulatory networks. Such insights offer valuable clues in understanding susceptibility to HIV infection and in crafting innovative treatments to alleviate the health challenges faced by this vulnerable infant population.

In the past five years, our efforts have been dedicated to the exploration of placental immunology, dissecting events occurring at the maternal-foetal interface and the factors that disrupt immune tolerance. By scrutinizing the human placenta and unpacking the repercussions of maternal HIV infection on cells at the foeto-maternal interface, we aim to provide evidence and comprehension regarding the heightened vulnerability of HEU infants to health issues.

At RIRCA, our mission is driven by collaboration, innovation, and a shared commitment to advancing knowledge and improving the lives of mothers and infants in Africa and beyond.