Publications

Cardiology division's recent yearly publications.
  1. B. Beyers, J. Cilliers, A. Doubell, P. Herbst, E. Ngarande, L. Joubert and A. Pecoraro Management and outcomes of patients with ST-segment elevation myocardial infarction in the Western Cape Province of South Africa. SA Heart 
  2. Almubarek, M., E. H. Louw, S. Griffith-Richards, C. Ackermann, N. Baines, H. Thomson, A. J. K. Pecoraro, C. F. N. Koegelenberg, E. M. Irusen, and B. W. Allwood. "Computed tomography chest imaging for the detection of pulmonary hypertension in patients with post-tuberculosis lung disease." African Journal of Thoracic and Critical Care Medicine (2025): e1948-e1948.   
  3. Rajah MR, Doubell A, Herbst P. High afterload rather than myocardial fibrosis predicts reduced ejection fraction in severe aortic stenosis with afterload mismatch. Open Heart. 2025 May 7;12(1):e003345. doi: 10.1136/openhrt-2025-003345. PMID: 40340895; PMCID: PMC12060870
  4. Rajah, M.R.; Marais, E.; Maarman, G.J.; Doubell, E.; Doubell, A.F.; Herbst, P.G. Utility of Serum Biomarkers of Myocardial Fibrosis in High-Gradient Severe Aortic Stenosis: An Explorative Cardiovascular Magnetic Resonance Imaging-Based Study. Diagnostics 2025, 15, 1143. https://doi.org/10.3390/diagnostics15091143 
  5. Hunter LD, Poerstamper S, Herbst PG, Doubell AF, Pienaar C, Taljaard JJ, Prozesky H, Janson JJ, Pecoraro AJ. Bartonella endocarditis: a complex diagnosis of blood culture-negative endocarditis in an endemic region of Africa. Open Heart. 2025 Aug 7;12(2):e003463. doi: 10.1136/openhrt-2025-003463. PMID: 40780843; PMCID: PMC12336616.
  6. Germishuys DC,  Doubell AF, Esterhuizen TM, Moses J. MobitzType 1 atrioventricular block: A retrospective assessment of the natural history and need for pacing in 45–64-year-olds. September 15, 2025 Cardiovasc J Afr 2025; 36: 420-434 Volume 36, Issue 3. https://doi.org/10.5830/CVJA-2025-049  
  7. Hassan K, Doubell A, Kyriakakis C, Joubert L, Zaharie D, Van Zyl G, Leisegang R, Herbst P. Contemporary study of acute myocarditis in South Africa: CAMISA. Open Heart. 2025 Jul 7;12(2):e002845. doi: 10.1136/openhrt-2024-002845. PMID: 40623892; PMCID: PMC12258367.
  8. Giliomee LJ, Verster J, Maposa I, Doubell A, Robbertse PS, Herbst P. Pericardial segmentation: a proposed model to quantify disease burden. Open Heart. 2025 Sep 23;12(2):e003512. doi: 10.1136/openhrt-2025-003512 . PMID: 40992795; PMCID: PMC12458675.
  9. H Weich, A Mazaza, SS Gharacholou, GW Barsness, S Khan and D Holmes. SASCI-Mayo Clinic Fellows webinar: Managing bleeding complications in acute coronary syndrome. SA Heart® 2025;22:191-195.DOI: https://doi.org/10.24170/22-03-7641 
  10. A Engelbrecht, AJK Pecoraro and AF Doubell. The prevalence, characteristics, associated comorbidities and medical management of patients with atrial fibrillation in a tertiary setting in the Western Cape. SA Heart® 2025;22:143-150. DOI: https://doi.org/10.24170/22-3-7422 
  11. S Potgieter, A Doubell, C Germishuys and J Moses. The prevalence, characteristics, associated comorbidities and medical management of patients with atrial fibrillation in a tertiary setting in the Western Cape. SA Heart® 2025;22:155-161. DOI: https://doi.org/10.24170/22-3-6802 
  12. Engelbrecht A, Doubell AF, Pecoraro AJ, Messika-Zeitoun D, Challenges of Infective Endocarditis in South Africa, a low- to middle-income country., Canadian Journal of Cardiology (2025), doi: https://doi.org/10.1016/j.cjca.2025.10.017. 
  13. Mann T, Minnies S, Gupta RK, Reeve BWP, Nyawo G, Palmer Z, Naidoo C, Doubell A, Pecoraro A, John TJ, Schubert P, Calderwood CJ, Chandran A, Theron G, Noursadeghi M. Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study. Lancet Microbe. 2025 Sep;6(9):101153. https://doi.org/10.1016/j.lanmic.2025.101153 . Epub 2025 Jul 14. PMID: 40675164.
  14. Hassan,  K.; Doubell,  A.; Kyriakakis,  C.; Joubert,  L.; van Zyl,  G.; Claassen,  M.; van Huyssteen,  R.; Zaharie,  D.; Leisegang,  R.; Herbst,  P. Parvovirus B19 Myocarditis: The Utility of Viral Load Assessment in Determining the Significance of a Virus Positive Biopsy in South Africa. Preprints 2025, 2025062404. https://doi.org/10.20944/preprints202506.2404.v1
  15. R. du Toit, S. Karamchant, T. Ollewagen, P. Herbst, A.F. Doubell, C. Smith. INTERLEUKIN-6 IN LUPUS MYOCARDITIS – FRIEND OR FOE. Annals of the Rheumatic Diseases, Volume 84, Supplement 1, 2025, Page 2186, ISSN 0003-4967, https://doi.org/10.1016/j.ard.2025.06.1822. 
  16. Kock,  L. G.; Laubscher,  R.; van der Merwe,  J.; Venter,  M. P.; Doubell,  A. F.; Herbst,  P. G. Evaluation of the Haemodynamic Behaviour of Stenosed Aortic Heart Valves Using Fuid Structure Interaction Modelling. Preprints 2025, 2025041780. https://doi.org/10.20944/preprints202504.1780.v1
  17. G Nyawo, C.C. Naidoo, B.G. Wu, B Kwok, J. C. Clemente, Yonghua Li, S Minnies, B Reeve, S Moodley, T-J John, S Karamchand, S Singh, A Pecararo, A Doubell, C Kyriakakis, Robin Warren, L.N. Segal, G Theron. Bad company? The pericardium microbiome in people investigated for tuberculous pericarditis in an HIV-prevalent setting. Microbes and Infection, Volume 27, Issue 3, 2025, 105434, ISSN 1286-4579. https://doi.org/10.1016/j.micinf.2024.105434 . 

 

  1. Nguyen ET, Ordovas K, Herbst P, Kozor R, Ng MY, Natale L, Nijveldt R, Salgado R, Sanchez F, Shah D, Stojanovska J, Valente AM, Westwood M, Plein S. Competency based curriculum for cardiovascular magnetic resonance: A position statement of the Society for Cardiovascular Magnetic Resonance. J Cardiovasc Magn Reson. 2024 Summer;26(1):100006. doi: 10.1016/j.jocmr.2023.100006. Epub 2023 Dec 22. PMID: 38215698; PMCID: PMC11211229.
  2. Lovelock, T., du Plessis, M., van der Westhuizen, C., Janson, J., Lawrence, C., Parker, A., Pecoraro, A., Prozesky, H., von Gottberg, A., & Taljaard, J. 2024 Feb 21. Non-toxigenic Corynebacterium diphtheriae endocarditis: A cluster of five cases. Southern African Journal of Infectious Diseases. [Online] 39:1
  3. Giliomee LJ, Doubell AF, Robbertse PS, John TJ, Herbst PG. Novel role of cardiovascular MRI to contextualise tuberculous pericardial inflammation and oedema as predictors of constrictive pericarditis. Front Cardiovasc Med. 2024 Mar 18;11:1329767. doi: 10.3389/fcvm.2024.1329767. PMID: 38562190; PMCID: PMC10982342.
  4. Robbertse PS, Doubell AF, Esterhuizen TM, Herbst PG. Antiretroviral therapy and HIV-associated cardiovascular disease: a prospective cardiac biomarker and CMR tissue characterization study. ESC Heart Fail. 2024 Apr;11(2):748-758. doi: 10.1002/ehf2.14603. Epub 2023 Dec 15. PMID: 38100145; PMCID: PMC10966217.
  5. Robbertse PS, Steyn J, Rajah MR, Doubell AF, Nachega JB, Herbst PG. Subclinical cardiovascular remodelling in HIV-infection: A multimodal case study of 2 serodiscordant, monozygotic twins. SA Heart J. 2024 Apr 26;21(1):48-57. doi: 10.24170/21-1-6322. PMID: 38737401; PMCID: PMC11087033
  6. Talle MA, Robbertse PS, Doubell AF, Lahri S, Herbst PG. Characterizing myocardial edema and fibrosis in hypertensive crisis with cardiovascular magnetic resonance imaging. Sci Rep. 2024 Oct 9;14(1):23509. doi: 10.1038/s41598-024-74099-9. PMID: 39379531; PMCID: PMC11461819.
  7. Rajah MR, Doubell AF, Herbst PG. Quantification of Replacement Fibrosis in Aortic Stenosis: A Narrative Review on the Utility of Cardiovascular Magnetic Resonance Imaging. Diagnostics (Basel). 2024 Oct 31;14(21):2435. doi: 10.3390/diagnostics14212435. PMID: 39518402; PMCID: PMC11544846.
  8. L D Hunter, S Poerstamper, P G Herbst, A F Doubell, C Pienaar, H Prozesky, J Taljaard, J T Jansen, A J K Pecoraro, Bartonella endocarditis: lessons learnt from an African cohort, European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.1960, https://doi.org/10.1093/eurheartj/ehae666.1960
  9. N Greeff EJ Langenegger PG Herbst C Lombard A Theron Disease spectrum and short-term outcomes of obstetric patients with cardiac disease admitted to an obstetric critical care unit in South Africa 2024 Southern African Journal of Anaesthesia and Analgesia 150-157 30 5 doi:10.36303/SAJAA.3120 https://journals.co.za/doi/abs/10.36303/SAJAA.3120
  10. Grobler, L.; Laubscher, R.; van der Merwe, J.; Herbst, P.G. Evaluation of Aortic Valve Pressure Gradients for Increasing Severities of Rheumatic and Calcific Stenosis Using Empirical and Numerical Approaches. Math. Comput. Appl. 2024, 29, 33. https://doi.org/10.3390/mca29030033
  11. Boodman C, Fongwen N, Pecoraro AJ, Mihret A, Abayneh H, Fournier PE, Gupta N, van Griensven J. Hidden Burden of Bartonella quintana on the African Continent: Should the Bacterial Infection Be Considered a Neglected Tropical Disease? Open Forum Infect Dis. 2023 Dec 27;11(2):ofad672. doi: 10.1093/ofid/ofad672. PMID: 38370291; PMCID: PMC10873695.
  12. Ntsekhe M, Doubell A. Eradicating rheumatic heart disease in Africa: have we made progress since the Drakensberg declaration? Front Cardiovasc Med. 2024 Nov 8;11:1485501. doi: 10.3389/fcvm.2024.1485501. PMID: 39582523; PMCID: PMC11581863.
  13. Megan Rajah, Anton Doubell, Philip Herbst, Kiosk 6R-TA-07 - Afterload Mismatch in Severe Aortic Stenosis: A Case of Inadequate Left Ventricular Hypertrophy or Not?, Journal of Cardiovascular Magnetic Resonance, Volume 26, Supplement 1, 2024, https://doi.org/10.1016/j.jocmr.2024.100752 https://www.sciencedirect.com/science/article/pii/S1097664724007439
  14. Mann T, Minnies S, Gupta RK, Reeve BW, Nyawo G, Palmer Z, Naidoo C, Doubell A, Pecararo A, John TJ, Schubert P, Calderwood CJ, Chandran A, Theron G, Noursadeghi M. Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis. medRxiv [Preprint]. 2024 Jul 3:2024.06.21.24309099. doi: 10.1101/2024.06.21.24309099. PMID: 38946942; PMCID: PMC11213046.
  15. Nyawo G, Naidoo CC, Wu BG, Kwok B, Clemente JC, Li Y, Minnies S, Reeve B, Moodley S, John TJ, Karamchand S, Singh S, Pecararo A, Doubell A, Kyriakakis C, Warren R, Segal LN, Theron G. Bad company? The pericardium microbiome in people investigated for tuberculous pericarditis in an HIV-prevalent setting. Microbes Infect. 2024 Nov 9:105434. doi: 10.1016/j.micinf.2024.105434. Epub ahead of print. PMID: 39528106.
  16. van Schalkwyk C, van Zyl BC, Herbst PG, Ackermann C. An audit of the establishment of a cardiac magnetic resonance imaging service in a public tertiary hospital setting in the Western Cape Province of South Africa. Pan Afr Med J. 2024 Sep 12;49:15. doi: 10.11604/pamj.2024.49.15.44617. PMID: 39711839; PMCID: PMC11662215.
  17. A Asomaning, S Karamchand, MY Chothia. Platypnoea–orthodeoxia syndrome in a patient on haemodialysis: a case report and scoping review. African Journal of Nephrology I Volume 27, No 1, 2024.
  18. Garelnabi M, Ntsekhe M, Doubell A, Aikawa M. Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities. Front Cardiovasc Med. 2024 Oct 22;11:1479281. doi: 10.3389/fcvm.2024.1479281. PMID: 39502195; PMCID: PMC11534761.
  19. Megan Rajah, Anton Doubell, Philip Herbst. A case-based narrative review on the structural myocardial changes associated with systolic dysfunction in severe aortic stenosis. DOI: https://doi.org/10.24170/21-3-5663. SA Heart Journal,Vol. 21 No. 3 (2024)
  20. Simon Poerstamper, Anton Doubell, Philip Herbst. Characteristics and outcomes of infective endocarditis in South Africa: A retrospective cohort study. DOI: https://doi.org/10.24170/21-3-4827. SA Heart Journal,Vol. 21 No. 3 (2024)
  21. Sashelin Naidoo, Alfonso Pecoraro, Jan Steyn, Anton Doubell, Jacques Janson. Short-term outcomes of secondary tricuspid regurgitation after left-sided heart valve surgery. DOI: https://doi.org/10.24170/21-3-6219. SA Heart Journal,Vol. 21 No. 3 (2024) 
  1. Liebenberg J, John TJ, Khalfey H, D'Andrea I, Kyriakakis C. Subacute dual stent thromboses in a COVID-19-positive patient. Cardiovasc J Afr. 2022 Mar 24;33:1-4. doi: 10.5830/CVJA-2022-003. Epub ahead of print. PMID: 35333278
  2. Louw, E, Baines, N, Maarman, G, Osman, M, Sigwadhi, L, Irusen, E, Koegelenberg, C, Doubell, A, Nathan, S, Channick, R, Allwood, B. The prevalence of pulmonary hypertension after successful tuberculosis treatment in a community sample of adult patients. Pulm Circ. 2023; 13:e12184. https://doi.org/10.1002/pul2.12184
  3. Talle, M.A.; Ngarande, E.; Doubell, A.F.; Herbst, P.G. Prevalence of Myocardial Injury and Myocardial Infarction in Patients with a Hypertensive Emergency: A Systematic Review. Diagnostics 2023, 13, 60. https://doi.org/10.3390/diagnostics13010060
  4. Robbertse PS, Doubell AF, Steyn J, Lombard CJ, Talle MA, Herbst PG. Altered cardiac structure and function in newly diagnosed people living with HIV: a prospective cardiovascular magnetic resonance study after the initiation of antiretroviral treatment. Int J Cardiovasc Imaging. 2023 Jan;39(1):169-182. doi: 10.1007/s10554-022-02711-y. Epub 2022 Aug 26. PMID: 36598696; PMCID: PMC9412796.
  5. J A Shaw, C F N Koegelenberg, M da Silva, B W Allwood, H Weich. Transcatheter vascular plugs for the treatment of massive haemoptysis from Rasmussen aneurysms S Afr Med J 2022;113(2):https://doi.org/10.7196/SAMJ…;
  6. Hunter LD, Doubell AF, Pecoraro AJK, Monaghan M, Lloyd G, Lombard C, Herbst PG. Morpho-mechanistic screening criteria for the echocardiographic detection of rheumatic heart disease. Heart. 2023 Apr 28:heartjnl-2022-322192. doi: 10.1136/heartjnl-2022-322192. Epub ahead of print. PMID: 37117004.
  7. Cilliers JD. The incidence and outcomes of high-risk acute coronary syndromes in Western Cape Province, South Africa: A prospective cohort study. S Afr Med J. 2023 May 5;113(5):25-29. PMID: 37170604.
  8. Laubscher R, Van Der Merwe J, Herbst P, Liebenberg J. Estimation of Simulated Left Ventricle Elastance Using Lumped Parameter Modelling and Gradient-Based Optimization With Forward-Mode Automatic Differentiation Based on Synthetically Generated Noninvasive Data. J Biomech Eng. 2023 Feb 1;145(2):021008. doi: 10.1115/1.4055565. PMID: 36082474.
  9. Talle MA, Doubell AF, Robbertse PS, Lahri S, Herbst PG. The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency. Diagnostics (Basel). 2023 Apr 30;13(9):1605. doi: 10.3390/diagnostics13091605. PMID: 37174996; PMCID: PMC10178101.
  10. du Toit R, Karamchand S, Doubell AF, Reuter H, Herbst PG. Lupus myocarditis: review of current diagnostic modalities and their application in clinical practice. Rheumatology (Oxford). 2023 Feb 1;62(2):523-534. doi: 10.1093/rheumatology/keac409. PMID: 35861382.
  11. Liebenberg, J., Doubell, A., Laubscher, R., & Herbst, P. (2023). In-silico modelling of the impact of hypertension on the mean transvalvular gradients in aortic stenosis. PLOS ONE, 18(6), e0286644. https://doi.org/10.1371/journal.pone.0286644
  12. Liebenberg J, Doubell A, Steyn J, Herbst P. Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis. Heart. 2023 Jul 24:heartjnl-2023-322727. doi: 10.1136/heartjnl-2023-322727. Epub ahead of print. PMID: 37487698.
  13. Talle, M.A.; Doubell, A.F.; Robbertse, P.-P.S.; Lahri, S.; Herbst, P.G. Cardiac Morphology, Function, and Left Ventricular Geometric Pattern in Patients with Hypertensive Crisis: A Cardiovascular Magnetic Resonance-Based Study. J. Cardiovasc. Dev. Dis. 2023, 10, 367. https://doi.org/10.3390/jcdd10090367
  14. Weich, H., Herbst, P., Smit, F., & Doubell, A. Transcatheter heart valve interventions for patients with rheumatic heart disease. Frontiers in Cardiovascular Medicine, 10, 1234165. https://doi.org/10.3389/fcvm.2023.1234165
  15. A RETROSPECTIVE AUDIT OF YOUNG ADULTS WHO RECEIVED PERMANENT PACEMAKERS AT A TEACHING HOSPITAL IN THE WESTERN CAPE, SOUTH AFRICA”, by Elrike Hugo* , Anton Frans Doubell, Jan Steyn and Jane Moses, published in “Frontiers in Cardiova
  16. Talle MA, Doubell AF, Robbertse PS, Lahri S, Herbst PG. Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study. Diagnostics (Basel). 2023 Sep 14;13(18):2943. doi: 10.3390/diagnostics13182943. PMID: 37761309; PMCID: PMC10527803.
  17. Rosenson RS, Burgess LJ, Ebenbichler CF, et al. Longer-Term Efficacy and Safety of Evinacumab in Patients With Refractory Hypercholesterolemia. JAMA Cardiol. Published online September 13, 2023. doi:10.1001/jamacardio.2023.2921
  18. Development and testing of a transcatheter heart valve with reduced calcification potential.  Hellmuth Weich , Lezelle Botes, Anton Doubell, Johan Jordaan, Angelique Lewies, Prennie Marimuthu, Johannes Van den Heever and Francis Smit, published in “Frontiers in Cardiovascular Medicine-Heart Valve Disease.
  19. Talle M, Doubell A, Robbertse PP, Lahri S, Herbst P. Clinical Profile of Patients with Hypertensive Emergency Referred to a Tertiary Hospital in the Western Cape Province of South Africa. Current Hypertension Reviews. 2023 Nov. DOI: 10.2174/0115734021266958231101094556. PMID: 37957866. 
  1. Knoetzen M, Robbertse PS, Parker A. Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient. IDCases. 2022 Feb 4;27:e01444. doi: 10.1016/j.idcr.2022.e01444. PMID: 35198387; PMCID: PMC8844763.
  2. Pecoraro AJK, Herbst PG, Joubert LH et al. Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study. S Afr Med J; Jan 2022
  3. Talle, M.A.; Ngarande, E.; Doubell, A.F.; Herbst, P.G. Cardiac Complications of Hypertensive Emergency: Classification, Diagnosis and Management Challenges. J. Cardiovasc. Dev. Dis. 2022, 9, 276. https://doi.org/10.3390/jcdd9080276
  4. Pecoraro AJ, Herbst PG, Doubell AF. Infective endocarditis in Africa: an urgent call for more data. Lancet Glob Health. 2022 Jan;10(1):e8-e9. doi: 10.1016/S2214-109X(21)00489-7. PMID: 34919860
  5. Hassan K, Doubell A, Kyriakakis C, Joubert L, Robbertse PP, Van Zyl G, Zaharie D, Herbst P. Comparing the findings and diagnostic sensitivity of cardiovascular magnetic resonance in biopsy confirmed acute myocarditis with infarct-like vs. heart failure presentation. J Cardiovasc Magn Reson. 2022 Dec 7;24(1):69. doi: 10.1186/s12968-022-00903-y. PMID: 36476480; PMCID: PMC9730564.
  6. Hassan K, Kyriakakis C, Doubell A, Van Zyl G, Claassen M, Zaharie D, Herbst P. Prevalence of cardiotropic viruses in adults with clinically suspected myocarditis in South Africa. Open Heart. 2022 Jan;9(1):e001942. doi: 10.1136/openhrt-2021-001942
  7. Hassan K, Doubell A, Herbst. Unpacking the mysteries of Parvovirus B19 Myocarditis. Vol. 19 No. 1 (2022): SA Heart Journal. doi: https://doi.org/10.24170/19-1….
  8. Hassan K, Kyriakakis C, Joubert L, Van Zyl G, Zaharie D, Doubell A, Herbst P. Routine use of fluoroscopic and real-time transthoracic echocardiographic guidance to ensure safety of right ventricular endomyocardial biopsy in a low-volume center. Catheter Cardiovasc Interv. 2022 Apr;99(5):1563-1571. doi: 10.1002/ccd.30070. Epub 2022 Jan 18.
  9. Lloyd H Joubert, Anton F Doubell, Eduard J Langenegger, Anna S Herrey, Lina Bergman, Karl Bergman, Catherine Cluver, Christelle Ackermann, Philippus G Herbst. Cardiac magnetic resonance imaging in preeclampsia complicated by pulmonary edema shows myocardial edema with normal left ventricular systolic function. Am J Obstet Gynecol. 2022 Mar 10;S0002-9378(22)00180-6. doi: 10.1016/j.ajog.2022.03.009. Online ahead of print
  10. Robbertse P, Doubell A, Innes S, Lombard C, Herbst P. Pulse wave velocity demonstrates increased aortic stiffness in newly diagnosed, antiretroviral naïve HIV infected adults: A case-control study. Medicine. A case-control study. Medicine 2022; First published online: doi:10.1097/MD.0000000000029721
  11. du Toit R, Karamchand S, Doubell AF, Reuter H, Herbst PG. Lupus myocarditis: review of current diagnostic modalities and their application in clinical practice. Rheumatology (Oxford). 2022 Jul 21:keac409. doi: 10.1093/rheumatology/keac409. Online ahead of print. PMID: 35861382
  12. Robbertse, PP.S., Doubell, A.F., Steyn, J. et al. Altered cardiac structure and function in newly diagnosed people living with HIV: a prospective cardiovascular magnetic resonance study after the initiation of antiretroviral treatment. Int J Cardiovasc Imaging (2022). https://doi.org/10.1007/s10554-022-02711-y
  13. Pecoraro AJK, Herbst PG, Janson JT, Wagenaar R, Ismail Z, Taljaard JJ, Prozesky HW, Pienaar C, Doubell AF. Early surgery determines prognosis in patients with infective endocarditis: outcome in patients managed by an Endocarditis Team-a prospective cohort study. Cardiovasc Diagn Ther. 2022 Aug;12(4):453-463. doi: 10.21037/cdt-21-590. PMID: 36033220; PMCID: PMC9412218.
  14. Laubscher R, van der Merwe J, Liebenberg J, Herbst P. Dynamic simulation of aortic valve stenosis using a lumped parameter cardiovascular system model with flow regime dependent valve pressure loss characteristics. Med Eng Phys. 2022 Aug;106:103838. doi: 10.1016/j.medengphy.2022.103838. Epub 2022 Jun 18. PMID: 35926953.
  15. Laubscher R, Van Der Merwe J, Herbst PG, Liebenberg J. Inference of Pulmonary Arterial Pressure using Non-invasive Measurements and Scientific Machine Learning Techniques. Preprints.org; 2022. DOI: 10.20944/preprints202208.0490.v1.
  16. Pecoraro AJK, Herbst PG, Pienaar C, Taljaard J, Prozesky H, Janson J, Doubell AF. Modified Duke/European Society of Cardiology 2015 clinical criteria for infective endocarditis: time for an update? Open Heart. 2022 May;9(1):e001856. doi: 10.1136/openhrt-2021-001856. PMID: 35534094; PMCID: PMC9086646.
  17. A. Esmail, A.F. Doubell, H. Piek, J.T. Janson and A.J.K. Pecoraro. Zoonotic Endocarditis: Is the feather mightier than the sword? Vol. 19 No. 1 (2022): SA Heart Journal. DOI: https://doi.org/10.24170/19-1…
  18. Hitzeroth J, Weich H, Scherman J. 2022 SASCI/SCTSSA joint consensus statement and guideline on transcatheter aortic valve implantation (TAVI) in South Africa. Cardiovasc J Afr. 2022 Sep 12;33:1-3. doi: 10.5830/CVJA-2022-049. Epub ahead of print. PMID: 36094812.
  19. Liebenberg J, John TJ, Khalfey H, D'Andrea I, Kyriakakis C. Subacute dual stent thromboses in a COVID-19-positive patient. Cardiovasc J Afr. 2022 Mar 24;33:1-4. doi: 10.5830/CVJA-2022-003. Epub ahead of print. PMID: 35333278.
  20. Eknewir S, John TJ, Bennji SM, Koegelenberg CFN. The utility of endobronchial ultrasound-guided transbronchial needle aspiration in a community with a high HIV and tuberculosis burden. Afr J Thorac Crit Care Med. 2022 May 5;28(1):10.7196/AJTCCM.2022.v28i1.156. doi: 10.7196/AJTCCM.2022.v28i1.156. PMID: 35814170; PMCID: PMC9255698.
  21. Weich HSVH, John T-J. Averted Catastrophic Transseptal Puncture: Percutaneous Transseptal Mitral Commissurotomy in a Patient With Undiagnosed Azygous Continuation of the Inferior Vena Cava. Indian Journal of Clinical Cardiology. 2022;3(3):160-162. doi:10.1177/26324636221081942
  22. Laubscher, R., Van Der Merwe, J., Herbst, P., and Liebenberg, J. (October 6, 2022). "Estimation of Simulated Left Ventricle Elastance Using Lumped Parameter Modelling and Gradient-Based Optimization With Forward-Mode Automatic Differentiation Based on Synthetically Generated Noninvasive Data." ASME. J Biomech Eng. February 2023; 145(2): 021008. https://doi.org/10.1115/1.4055565
  23. Laubscher R, Van Der Merwe J, Herbst PG, Liebenberg J. Estimation of Pulmonary Arterial Pressure Using Simulated Non-Invasive Measurements and Gradient-Based Optimization Techniques. Mathematical and Computational Applications. 2022; 27(5):83. https://doi.org/10.3390/mca27050083
  24. Joubert LH, Doubell AF, Herbst PG. Why don't all women with preeclampsia with severe features develop pulmonary edema? Am J Obstet Gynecol. 2022 Aug 23:S0002-9378(22)00675-5. doi: 10.1016/j.ajog.2022.08.033. Epub ahead of print. PMID: 35998743.
  25. K M Hassan, C G Kyriakakis, L H Joubert, A F Doubell, S D Zaharie, G U Van Zyl, P G Herbst, The contemporary study of acute myocarditis in South Africa – CAMISA, European Heart Journal, Volume 42, Issue Supplement_1, October 2021,ehab724.1747, https://doi.org/10.1093/eurheartj/ehab724.1747
  26. Laubscher, R., Liebenberg, J., Herbst, P. (2022). Non-invasive estimation of left ventricle elastance using a multi-compartment lumped parameter model and gradient-based optimization with forward-mode automatic differentiation. arXiv. https://doi.org/10.48550/arXiv.2205.12330
  27. JOHN TJ, DA SILVA MB, WEICH HSVH. Vascular Plugs—Novel Therapeutic Management of Hemoptysis Secondary to Ruptured Rasmussen’s Aneurysm? Indian Journal of Clinical Cardiology 2022; 3(4):188-190.
  28. LU M, CHEN W, LEI Z, DAI S, HOU C, DU S, GEAKE J, BHURAYANONTACHA R, KARAMCHAND S, CHAN ED, JIN Q, LI H. Image-guided percutaneous biopsy and pathological diagnosis in atypical tuberculous spondylitis: a case series and clinical outcomes. Annals of Translational Medicine 2022; 10(20):1140, 10 pages.
  29. MOOLLA MS, MULLER WK. Longstanding unrepaired tetralogy of Fallot. Pan African Medical Journal 2022; 42:183, 2 pages.
  30. RISTOW B, DOUBELL AF, DERMAN EW, HEINE M. Change in resting heart rate and risk for all-cause mortality. European Journal of Preventive Cardiology 2022; 29(7): e249-e254.
  31. Robbertse, PP.S., Doubell, A.F., Lombard, C.J. et al. Evolution of myocardial oedema and fibrosis in HIV infected persons after the initiation of antiretroviral therapy: a prospective cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 24, 72 (2022). https://doi.org/10.1186/s12968-022-00901-0
  1. Hellmuth S. vH. Weich, Thadathilankal-Jess John, Lloyd Joubert, Jane Moses, Philip Herbst, Anton Doubell, Dynamic Left Ventricular Outflow Tract Obstruction Post– Transcatheter Aortic Valve Replacement, JACC: Case Reports 2021; Volume 3 (6):871- 874. ISSN 2666-0849. Doi: 10.1016/j.jaccas.2021.04.035.
  2. J J Liebenberg, A Doubell, J van Wyk, M Kidd, T Mabin, H Weich. Predictors of 1-year survival in South African transcatheter aortic valve implant candidates. S Afr Med J 2020;110(6):491-496. https://doi.org/10.7196/SAMJ.2020.v110i6.14123
  3. Pennefather C, Esterhuizen T, Doubell A, Decloedt EH. The 12-month period prevalence and cardiac manifestations of HIV in patients with acute coronary syndrome at a tertiary hospital in Cape Town, South Africa: a retrospective cross-sectional study. BMC Infect Dis. 2021 Jul 7;21(1):657. doi: 10.1186/s12879-021-06367-2. PMID: 34233630; PMCID: PMC8261984.
  4. Doubell J, Kyriakakis C, Weich H, Herbst P, Pecoraro A, Moses J, Griffiths B, Snyman HW, Kabwe L, Du Toit R, Joubert L, Hassan K, Doubell A. Radial artery dilatation to improve access and lower complications during coronary angiography: the RADIAL trial. EuroIntervention. 2021 Mar 19;16(16):1349-1355
  5. Pecoraro AJK, Herbst PG, Pienaar C, Taljaard J, Prozesky H, Janson J, Doubell AF. Bartonella species as a cause of culture-negative endocarditis in South Africa. Eur J Clin Microbial Infect Dis. 2021 Apr 7. doi: 10.1007/s10096-021-04239-w. Epub ahead of print. PMID: 33829350
  6. Pecoraro AJK, Pienaar C, Herbst PG et al. Causes of infective endocarditis in the Western Cape, South Africa: A prospective cohort study utilising a set protocol for organism detection and central decision making by an Endocarditis team. BMJ Open 2021;0:e053169
  7. du Toit R, Herbst PG, Ackerman C, Pecoraro AJ, Claassen D, Cyster HP, Reuter H, Doubell AF. Outcome of clinical and subclinical myocardial injury in systemic lupus erythematosus - A prospective cohort study. Lupus. 2021 Feb;30(2):256-268. doi: 10.1177/0961203320976960. Epub 2020 Dec 1. PMID: 33525979.
  8. Hunter LD, Doubell AF, Pecoraro AJK, Monaghan M, Lloyd G, Lombard CJ, Herbst PG. The variable spectrum of anterior mitral valve leaflet restriction in rheumatic heart disease screening. Echocardiography. 2021 May;38(5):729-736. doi: 10.1111/echo.15039. Epub 2021 Apr 13. PMID: 33847025.
  9. du Toit R, Reuter H, Walzl G, Snyders C, Chegou NN, Herbst PG, Doubell AF. Serum cytokine levels associated with myocardial injury in systemic lupus erythematosus. Rheumatology (Oxford). 2021 Apr 6;60(4):2010-2021. doi: 10.1093/rheumatology/keaa540. PMID: 33221897
  10. Sothmann PJ, Groenewald WA, Doubell AF, Pitcher RD. TYPICAL VALUES OF DOSIMETRIC DATA FOR CARDIAC FLUOROSCOPY-GUIDED PROCEDURES IN A SOUTH AFRICAN TEACHING HOSPITAL. Radiat Prot Dosimetry. 2021 Nov 12;196(3-4):153-158. doi: 10.1093/rpd/ncab143. PMID: 34595514
  11. Luke D Hunter, Alfonso J K Pecoraro, Anton F Doubell, Mark J Monaghan, Guy W Lloyd, Carl J Lombard, Philip G Herbst. Screening for subclinical rheumatic heart disease: Addressing borderline disease in a real-world setting. European Heart Journal Open. 2021. 1(3): Nov 2021, oeab041, https://doi.org/10.1093/ehjop…
  12. Rudolf Du Toit, Anton Doubell, Mark Abelson, Farrel Hellig, Adie Horak, Thomas Mabin, Eric Klug, Elizabeth Schaafsma, Jacques Van Wyk, Jacques Scherman, Mpiko Ntsekhe, Hellmuth Weich. The South African SHARE-TAVI registry: incidence and risk factors leading to conduction disturbances requiring permanent pacemaker implantation. SA Heart J. 2021;18:88-95
  13. Thadathilankal-Jess John, Jo Bodenstein, Philip Herbst. Critical thinking in cardiovascular imaging: hypertrophic cardiomyopathy and anterior mitral valve cleft. SA Heart 2021;18:150-151
  14. K M Hassan, C G Kyriakakis, L H Joubert, A F Doubell, S D Zaharie, G U Van Zyl, P G Herbst, The contemporary study of acute myocarditis in South Africa – CAMISA, European Heart Journal, Volume 42, Issue Supplement_1, October 2021, ehab724.1747, https://doi.org/10.1093/eurheartj/ehab724.1747
  15. Bergman L, Bergman K, Langenegger E, Moodley A, Griffith-Richards S, Wikström J, Hall D, Joubert L, Herbst P, Schell S, van Veen T, Belfort M, Tong SYC, Walker S, Hastie R, Cluver C. PROVE-Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia. Cells. 2021 Apr 20;10(4):959. doi: 10.3390/cells10040959. PMID: 33924230; PMCID: PMC8074755.
  16. Gerhard van Wyk, Hellmuth Weich, Zirkia Joubert, Louis Johann de Jager, Kevin McCree, Thadathilankal-Jess John, Extensive pulmonary metastases in young boy with primary cardiac angiosarcoma: a case report, European Heart Journal - Case Reports, Volume 5, Issue 1, January 2021, ytaa473, https://doi.org/10.1093/ehjcr/ytaa473
  17. Robbertse P, Doubell A, Nachega J and Herbst P. The hidden continuum of HIV- associated cardiomyopathy: A focused review with case reports. SA Heart. 2021; 18:126-135
  1. John T-J, Muller W, Moses J. Palpitations in a well 27 year old woman. Heart 2020;106:1368.Heart 2020;106:1368. doi:10.1136/heartjnl-2020-316996
  2. Jane Moses, Anton Doubell, Developing a new electrophysiology service and training platform - narrowing the gap (Editorial). SA Heart 2020; 17(2):140-143
  3. Ashley Chin, Jane Moses, Andrew Thornton, Arrhythmias and COVID-19 infection. SA Heart 2020; 17(3):362-369. DOI: 10.24170/17-3-4384
  4. Luke D. Hunter, Carl J. Lombard, Mark J. Monaghan, Guy W. Lloyd, Brandon M. Franckeiss, Alfonso J.K. Pecoraro,  Anton F. Doubell, Philip G. Herbst. Screening for rheumatic heart disease: The reliability of anterior mitral valve leaflet thickness measurement. Echocardiography 2020. First published:10 June 2020  https://doi.org/10.1111/echo.14751
  5. John TJ, John K. What Is the Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive Patients with Diabetes? Can J Cardiol 2020 Jun;36(6):969.e3. doi: 10.1016/j.cjca.2020.03.049. Epub 2020 Apr 8.PMID: 2299779
  6. Thadathilankal-Jess John, Karim Hassan, Hellmuth Weich. Donning and doffing of personal protective equipment (PPE) for angiography during the COVID-19 crisis. Eur Heart J 2020 May 14;41(19):1786-1787. doi: 10.1093/eurheartj/ehaa283.
  7. John TJ, John K. Renin-angiotensin-aldosterone system dysregulation and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Eur Heart J  2020 Jun 7;41(22):2126-2127. doi: 10.1093/eurheartj/ehaa423
  8. LD Hunter, G Lloyd, M Monaghan AJK Pecoraro, AF Doubell, PG Herbst. Congenital bicuspid aortic valve: Differential prevalence across different South African population groups. South African Medical Journal 2020. In press
  9. Catherine Anne Cluver, Philip Herbst, Stephanie Griffith-Richards, Muhammed Hassan, Brian Allwood. Coarctation of the aorta: a rare cause of severe hypertension in pregnancy. Lancet 2020. In press.
    LD Hunter, MJ Monaghan, GW Lloyd, CJ Lombard, AJK Pecoraro, AF Doubell, PG Herbst. Inter-scallop separations of the posterior mitral valve leaflet: a solution to the ‘borderline RHD’ conundrum? Open Heart 2020:7:e001452. Doi: 10.1136/openhrt-2020-001452
  10. Pecoraro AJ, Doubell AF. Infective endocarditis in South Africa. Cardiovasc Diagn Ther. 2020 Apr;10(2):252-261
  11. Joubert LH, Herbst PG, Doubell AF, Pecoraro AJK. Clinical v. laboratory-based screening for COVID19 in asymptomatic patients requiring acute cardiac care. S Afr Med J. 2020 Sep 29;110(11):1064
  12. Ruchika Meel, Blanche Cupido, Alfonso Pecoraro, Anton Doubell, Wayne Lubbe, Ntobeko A. B. Ntusi. COVID-19 and cardiovascular imaging: a guide for the practicing clinician. SA Heart 2020; 17:306-312
  13. Hunter LD, Monaghan M, Lloyd G, Lombard C, Pecoraro AJK, Doubell AF, Herbst PG. Interscallop separations of the posterior mitral valve leaflet: a solution to the 'borderline RHD' conundrum? Open Heart. 2020 Nov;7(2): e001452
  14. Hunter LD, Lloyd GW, Monaghan MJ, Pecoraro AJK, Doubell AF, Herbst PG. Congenital bicuspid aortic valve: Differential prevalence across different South African population groups. S Afr Med J. 110 (8): 706
  15. Hunter LD, Lombard CJ, Monaghan MJ, Lloyd GW, Franckeiss BM, Pecoraro AJK, Doubell AF, Herbst PG. Screening for rheumatic heart disease: The reliability of anterior mitral valve leaflet thickness measurement. Echocardiography. 2020 Jun;37(6):808-814.
  16. du Toit R, Herbst PG, Ackerman C, Pecoraro AJ, du Toit RH, Hassan K, Joubert LH, Reuter H, Doubell AF. Myocardial injury in systemic lupus erythematosus according to cardiac magnetic resonance tissue characterization: clinical and echocardiographic features. Lupus. 2020 Oct;29(11):1461-1468. doi: 10.1177/0961203320936748. Epub 2020 Jul 6. PMID: 32631204.
  17. Pecoraro, A., Janson, J. & Cilliers, J.D. Cor triatriatrum or divided left atrium presenting as mitral stenosis in an adult patient. Echo Res Pract 7, I11–I13 (2020). https://doi.org/10.1530/ERP-20-0016
  18. Pecoraro AJK, Herbst PG, Joubert LH. Dwindling myocardial infarctions. Eur Heart J. 2020 Oct 1;41(37):3497-3499. doi: 10.1093/eurheartj/ehaa619. PMID: 33085965
  19. John TJ, Pecoraro A, Weich H, Joubert L, Griffiths B, Herbst P. The de Winter's pattern revisited: a case series. Eur Heart J Case Rep. 2020 Nov 26;4(6):1-5. doi: 10.1093/ehjcr/ytaa402. PMID: 33442615; PMCID: PMC7793130.
  20. Jansen van Rensburg R, Doubell AF, Herbst PG. Right ventricle dilatation: the big five. Heart. 2020 Mar;106(6):426-454. doi: 10.1136/heartjnl-2019-315945. PMID: 32098792.
  21. Weich HSVH, Marwick PC, Park KS, Proxenos MR, Lehmann M, Snyman HW, Levin AI, Doubell AF. Balloon Aortic Valvuloplasty Using a Non-Occlusive Balloon Catheter: First Animal Experience. Cardiovasc Eng Technol. 2020 Feb;11(1):59-66. doi: 10.1007/s13239-019-00442-1. Epub 2019 Nov 18. PMID: 31741174.
  22. Liebenberg JJ, Doubell A, Van Wyk J, Kidd M, Mabin T, Weich H. Predictors of 1-year survival in South African transcatheter aortic valve implant candidates. S Afr Med J. 2020 May 29;110(6):491-496. doi: 10.7196/SAMJ.2020.v110i6.14123. PMID: 32880560.
  23. Beyers BD, Doubell AF, Griffiths B, Jalavu T. Evaluating the time interval from diagnosis to fibrinolysis at centres in the drainage area of Tygerberg Hospital, Cape Town, South Africa. S Afr Med J. 2020 Mar 30;110(4):327-331. doi: 10.7196/SAMJ.2020.v110i4.14330. PMID: 32657746.
  24. John TJ, Kyriakakis C, Zachariah D, Doubell A. Inferior ST-elevation myocardial infarction managed with a pharmacoinvasive strategy and conservative management of delayed atrioventricular block: classical case report. Eur Heart J Case Rep. 2020 Dec 7;4(6):1-7. doi: 10.1093/ehjcr/ytaa375. PMID: 33628991; PMCID: PMC7891234.
  25. Robert S. Rosenson, Lesley J. Burgess, Christoph F. Ebenbichler, Seth J. Baum, Erik S.G. Stroes, Shazia Ali, Nagwa Khilla, Robert Hamlin, Robert Pordy, Yuping Dong, Vladimir Son, and Daniel Gaudet. Evinacumab in Patients with Refractory Hypercholesterolemia. New England Journal of Medicine. November15, 2020, DOI: 10.1056/NEJMoa2031049
  26. R Delport, A Vachiat, A Snyders, D Kettles and H Weich. Decline in acute coronary syndrome hospitalisation rates during COVID-19 lockdown in private hospitals in South Africa. SAHeart 2020;17:264-265
  27. John TJ, Pecoraro A, Weich H, Joubert L, Griffiths B, Herbst P. The de Winter's pattern revisited: a case series. Eur Heart J Case Rep. 2020 Nov 26;4(6):1-5. doi: 10.1093/ehjcr/ytaa402. PMID: 33442615; PMCID: PMC7793130.
  28. K A Knipe, E J Langenegger, W Muller, P Herbst. Impact of manual uterine displacement and left lateral tilt on echocardiographical velocity time intergral (stroke volume) in advanced pregnancy. South African Journal of Obstetrics and Gynaecology. 2020, Vol. 26, No. 2
  29. van Wyk G, Weich H, Joubert Z, de Jager LJ, McCree K, John TJ. Extensive pulmonary metastases in young boy with primary cardiac angiosarcoma: a case report. Eur Heart J Case Rep. 2020 Dec 11;5(1):ytaa473. doi: 10.1093/ehjcr/ytaa473. PMID: 33644646; PMCID: PMC7898572.