Rese​​arch

Our research involved the study of the fundamental biology of genetic material of both humans and organism to provide knowledge and build capacity that informs public health policy and practices. Our two main fields include tuberculosis (TB) and inherited genetic disorders. Notably, these research efforts extend beyond the field of human disease into areas such as wildlife management and veterinary disease in the case of TB. The quality of our research is further enhanced through national and international collaboration with world-class leaders in the field.

Animal TB

The Animal TB Research Group uses a One Health approach to TB research at wildlife, livestock, human, and environmental interfaces.

Anxiety disorders

Psychiatric genetics

Posttraumatic stress disorder (PTSD)

Obsessive-compulsive disorder (OCD

BIOINFORMATICS RESEARCH UNIT

The Bioinformatics Research Unit is a group of researchers engaged in data management, developing computational analysis pipelines, and assisting other investigators with the computational, bioinformatics and statistical analyses of their research data.

Clinical Mycobacteriology and Epidemiology (CLIME)

Mycobacteriology: Host-Pathogen Mycobactomics

The overall research goal of the Stellenbosch University Host-Pathogen Mycobactomics group is to gain a better understanding of how the pathogen Mycobacterium tuberculosis interacts with its host to cause disease.

Medical Genetics & Genetic Counselling

'Giving Medical Care, Genetic Counselling and Information for Families with Genetic Conditions and other Birth Defects'

Parkinson's Disease Research Group

We are a multidisciplinary research group focusing on investigating the genetic aetiology of Parkinson's disease (PD) and studying the molecular mechanisms leading to the development of the disorder.

RARE DISEASE GENOMICS

The Rare Disease Genomics Research Group is housed within the Biomedical Research Institute at the Tybergerg Medical Campus of Faculty of Medicine and Health Sciences, Stellenbosch University.

Centre for Tuberculosis

The SAMRC Centre for Tuberculosis Research (CTR) is housed within the Stellenbosch University’s Division of Molecular Biology and Human Genetics (MBHG) along with the DSI-NRF Centre of Excellence for Biomedical TB Research (CBTBR).

HOST-DIRECTED THERAPIES

Developing and testing inhibitors that are active against the enzymes of mycothiol/ergothioneine and Nitrogen metabolism pathways in Mycobacterium tuberculosis as possible new antitubercular drugs.

TB GENOMICS

The Tuberculosis Genomics (TB Genomics) research group focuses on comparative omics technologies leveraging whole-genome sequencing (WGS), transcriptomics using RNA-seq, and proteomics to investigate the epidemiology, drug resistance mechanisms and evolution of Mycobacterium tuberculosis complex (MTBC) and Nontuberculous Mycobacteria (NTM).

Tuberculosis Host Genetics

Our focus is on finding the genetic underpinnings of TB. Although one third of the world’s population is infected with M. tuberculosis, the vast majority will never develop any clinical disease.